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aav6 rep cap  (Cell Biolabs Inc)

 
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    Structured Review

    Cell Biolabs Inc aav6 rep cap
    Eight embryos were injected in utero at E15.5 with a pooled barcoded library of seven capsids (AAV9, AAV-DJ, AAV1, <t>AAV6,</t> CAP-B10, PHP.eB, X1.1) at equal concentrations and collected at E18.5. Data were analyzed using linear mixed effects models with tissue, capsid, and normalized reads as fixed effects, and biological replicates as a random effect, with AAV9 set as the reference capsid. A-B) Normalized DNA (A) and RNA (B) abundance of each capsid in cortex, caudal brain, eyes, liver, heart, and lung, relative to AAV9, quantified by NGS. Brain-biased capsids (PHP.eB, CAP-B10, X1.1; tropism established in adult mice) showed no statistically significant enrichment in CNS tissues or depletion in liver (all p > 0.05). C-D) Normalized DNA (C) and RNA (D) abundance in gonads (ovaries and testes; n = 2 female, n = 6 male).
    Aav6 Rep Cap, supplied by Cell Biolabs Inc, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/aav6 rep cap/product/Cell Biolabs Inc
    Average 86 stars, based on 1 article reviews
    aav6 rep cap - by Bioz Stars, 2026-06
    86/100 stars

    Images

    1) Product Images from "Defining a Midgestational Window for In Utero Genome Editing of the Fetal Murine Cortex"

    Article Title: Defining a Midgestational Window for In Utero Genome Editing of the Fetal Murine Cortex

    Journal: bioRxiv

    doi: 10.64898/2026.04.28.721509

    Eight embryos were injected in utero at E15.5 with a pooled barcoded library of seven capsids (AAV9, AAV-DJ, AAV1, AAV6, CAP-B10, PHP.eB, X1.1) at equal concentrations and collected at E18.5. Data were analyzed using linear mixed effects models with tissue, capsid, and normalized reads as fixed effects, and biological replicates as a random effect, with AAV9 set as the reference capsid. A-B) Normalized DNA (A) and RNA (B) abundance of each capsid in cortex, caudal brain, eyes, liver, heart, and lung, relative to AAV9, quantified by NGS. Brain-biased capsids (PHP.eB, CAP-B10, X1.1; tropism established in adult mice) showed no statistically significant enrichment in CNS tissues or depletion in liver (all p > 0.05). C-D) Normalized DNA (C) and RNA (D) abundance in gonads (ovaries and testes; n = 2 female, n = 6 male).
    Figure Legend Snippet: Eight embryos were injected in utero at E15.5 with a pooled barcoded library of seven capsids (AAV9, AAV-DJ, AAV1, AAV6, CAP-B10, PHP.eB, X1.1) at equal concentrations and collected at E18.5. Data were analyzed using linear mixed effects models with tissue, capsid, and normalized reads as fixed effects, and biological replicates as a random effect, with AAV9 set as the reference capsid. A-B) Normalized DNA (A) and RNA (B) abundance of each capsid in cortex, caudal brain, eyes, liver, heart, and lung, relative to AAV9, quantified by NGS. Brain-biased capsids (PHP.eB, CAP-B10, X1.1; tropism established in adult mice) showed no statistically significant enrichment in CNS tissues or depletion in liver (all p > 0.05). C-D) Normalized DNA (C) and RNA (D) abundance in gonads (ovaries and testes; n = 2 female, n = 6 male).

    Techniques Used: Injection, In Utero



    Similar Products

    aav6 rep cap  (Cell Biolabs Inc)
    86
    Cell Biolabs Inc aav6 rep cap
    Eight embryos were injected in utero at E15.5 with a pooled barcoded library of seven capsids (AAV9, AAV-DJ, AAV1, <t>AAV6,</t> CAP-B10, PHP.eB, X1.1) at equal concentrations and collected at E18.5. Data were analyzed using linear mixed effects models with tissue, capsid, and normalized reads as fixed effects, and biological replicates as a random effect, with AAV9 set as the reference capsid. A-B) Normalized DNA (A) and RNA (B) abundance of each capsid in cortex, caudal brain, eyes, liver, heart, and lung, relative to AAV9, quantified by NGS. Brain-biased capsids (PHP.eB, CAP-B10, X1.1; tropism established in adult mice) showed no statistically significant enrichment in CNS tissues or depletion in liver (all p > 0.05). C-D) Normalized DNA (C) and RNA (D) abundance in gonads (ovaries and testes; n = 2 female, n = 6 male).
    Aav6 Rep Cap, supplied by Cell Biolabs Inc, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/aav6 rep cap/product/Cell Biolabs Inc
    Average 86 stars, based on 1 article reviews
    aav6 rep cap - by Bioz Stars, 2026-06
    86/100 stars
    		  Buy from Supplier

    Image Search Results


    Eight embryos were injected in utero at E15.5 with a pooled barcoded library of seven capsids (AAV9, AAV-DJ, AAV1, AAV6, CAP-B10, PHP.eB, X1.1) at equal concentrations and collected at E18.5. Data were analyzed using linear mixed effects models with tissue, capsid, and normalized reads as fixed effects, and biological replicates as a random effect, with AAV9 set as the reference capsid. A-B) Normalized DNA (A) and RNA (B) abundance of each capsid in cortex, caudal brain, eyes, liver, heart, and lung, relative to AAV9, quantified by NGS. Brain-biased capsids (PHP.eB, CAP-B10, X1.1; tropism established in adult mice) showed no statistically significant enrichment in CNS tissues or depletion in liver (all p > 0.05). C-D) Normalized DNA (C) and RNA (D) abundance in gonads (ovaries and testes; n = 2 female, n = 6 male).

    Journal: bioRxiv

    Article Title: Defining a Midgestational Window for In Utero Genome Editing of the Fetal Murine Cortex

    doi: 10.64898/2026.04.28.721509

    Figure Lengend Snippet: Eight embryos were injected in utero at E15.5 with a pooled barcoded library of seven capsids (AAV9, AAV-DJ, AAV1, AAV6, CAP-B10, PHP.eB, X1.1) at equal concentrations and collected at E18.5. Data were analyzed using linear mixed effects models with tissue, capsid, and normalized reads as fixed effects, and biological replicates as a random effect, with AAV9 set as the reference capsid. A-B) Normalized DNA (A) and RNA (B) abundance of each capsid in cortex, caudal brain, eyes, liver, heart, and lung, relative to AAV9, quantified by NGS. Brain-biased capsids (PHP.eB, CAP-B10, X1.1; tropism established in adult mice) showed no statistically significant enrichment in CNS tissues or depletion in liver (all p > 0.05). C-D) Normalized DNA (C) and RNA (D) abundance in gonads (ovaries and testes; n = 2 female, n = 6 male).

    Article Snippet: Self-complementary pAAVs were generated from pscAAV-CAG-GFP, a gift from Mark Kay (Addgene, 83279). pAAV2/1 (gift from James M. Wilson; Addgene plasmid #112862), pAAV2/2 (gift from Melina Fan; Addgene plasmid #104963), AAV3 rep-cap (Cell Biolabs, VPK-423), AAV4 rep-cap (Cell Biolabs, VPK-424), pAAV2/5 (gift from Melina Fan; Addgene plasmid #104964), AAV6 rep-cap (Cell Biolabs, VPK-426), pAAV2/7 (gift from James M. Wilson; Addgene plasmid #112863), pAAV2/8 (gift from James M. Wilson; Addgene plasmid #112864), pUCmini-iCAP-AAV-PHP.eB13 (Addgene #103005), pUCmini-iCAP-AAV.CAP-B10 (Addgene #175004), AAV-DJ rep-cap (Cell Biolabs, VPK-420-DJ), and pUCmini-iCAP-AAV9-X1.1 (Addgene #196836) were used for production of AAVs together with the adenoviral helper plasmid pHelper (Agilent Technologies, #240071).

    Techniques: Injection, In Utero